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pubmed: 0001-5555
Granulocyte-colony Stimulating Factor-producing Primary Cutaneous Anaplastic Large Cell Lymphoma with Cerebral Metastasis.
Kasuya A, Hirakawa S, Hashizume H, Tokura Y Granulocyte-colony Stimulating Factor-producing Primary Cutaneous Anaplastic Large Cell Lymphoma with Cerebral Metastasis. Acta Derm Venereol. 2012 May 8; Authors: Kasuya A, Hirakawa S, Hashizume H, Tokura Y Abstract Abstract is missing (Letter). PMID: 22565644 [PubMed - as supplied by publisher]
Latest Issue of American Journal of Clinical Dermatology
Topical Antimicrobial Treatment of Acne Vulgaris: An Evidence-Based Review
Gamble, RyanDunn, JeffDawson, AnnelisePetersen, BrianMcLaughlin, LaurenSmall, AlisonKindle, ScottDellavalle, Robert P.
Archives of Dermatological Research (Browse Results)
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case–control study
Fri, 11 May 2012 05:53:45 -0000
Abstract Melanoma is one of the most aggressive human cancers. The vitamin D system contributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect to melanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case–control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmental markers used in the clinic today. A panel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00403-012-1243-3Authors Annika Schäfer, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanySteffen Emmert, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyJochen Kruppa, Institute of Medical Biometry and Statistics, University Lübeck, University Hospital Schleswig–Holstein, Campus Lübeck, Maria-Goeppert-Straße 1, 23562 Lübeck, GermanySteffen Schubert, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyMladen Tzvetkov, Department of Clinical Pharmacology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyRotraut Mössner, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyKristian Reich, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyCarola Berking, Department of Dermatology, Ludwig-Maximilians-University of Munich, Frauenlobstrasse 9-11, 80337 Munich, GermanyMatthias Volkenandt, Dermatologikum Hamburg, Stephansplatz 5, 20354 Hamburg, GermanyClaudia Pföhler, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, GermanyMichael P. Schön, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyThomas Vogt, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, GermanyInke R. König, Institute of Medical Biometry and Statistics, University Lübeck, University Hospital Schleswig–Holstein, Campus Lübeck, Maria-Goeppert-Straße 1, 23562 Lübeck, GermanyJörg Reichrath, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, Germany Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest Articles
The hereditary angioedema burden of illness study in Europe (HAE-BOIS- Europe): background and methodology
Anette BygumEmel Aygören-PürsünTeresa CaballeroKathleen BeusterienShadi GholizadehPatience MusingarimiSuzanne WaitHenrik Boysen Thu, 26 Apr 2012 00:00:00 -0000
Background: Hereditary angioedema (HAE) is a rare but serious disease marked by swelling attacks in the extremities, face, trunk, airway, or abdominal areas that can be spontaneous or the result of trauma and other triggers. It can be life-threatening due to the risk of asphyxiation. While there have been major advancements in our understanding of the immunogenetics of HAE, there are significant gaps in the literature regarding understanding of the humanistic and economic impact of the disease, particularly in Europe. The purpose of the HAE Burden of Illness Study-Europe (HAE-BOIS-Europe), the development and methodology of which is described here, is to better understand the management and impact of HAE from the patient perspective in Europe. Methods: This is a cross-sectional study being conducted in Denmark, Germany and Spain. The study is open to patients ages 12 and older with a diagnosis of HAE-I or HAE-II. Data collection includes: (i) a survey on individuals' health care resource use, direct and indirect medical costs, impact on work and school, treatment satisfaction, and emotional functioning (via the Hospital Anxiety and Depression Scale); and (ii) one-on-one interviews to collect detailed descriptive data and patient testimonials on the impact of HAE on patients' health-related quality of life. Conclusion: The present manuscript describes the development and plans for implementing a multi-country European study with the aim of characterizing the humanistic and economic burden of HAE from the patient perspective. This study will help raise awareness of HAE as a rare but debilitating condition with wide-ranging impacts.
Dermatology : Last 20 articles
Weight Loss and Its Relation to Fat Aspiration Yields in Liposuction: A Survey in 48 Patients
Dermatology (DOI:10.1159/000338894)
pubmed: 1167-1122
(Carpe)DIEM - dermatological indications for electron microscopy: Ehlers Danlos syndrome.
Guenova E, Schaller M (Carpe)DIEM - dermatological indications for electron microscopy: Ehlers Danlos syndrome. Eur J Dermatol. 2012 Jan-Feb;22(1):161 Authors: Guenova E, Schaller M PMID: 22370172 [PubMed - indexed for MEDLINE]
Exogenous Dermatology : Last 20 articles
Author Index Vol. 3, No. 4, 2004
Tue, 31 Jan 2006 00:00:00 +0100
Exog Dermatol 2004;3:201-202 (DOI:10.1159/000091311)
Expert Reviews: Expert Review of Dermatology: Table of Contents
Why are there so few effective treatments for pigmentary disorders of the skin?
info@expert-reviews.com (Rebat M Halder et al) Tue, 27 Mar 2012 18:02:35 -0000
Expert Review of Dermatology , April 2012, Vol. 7, No. 2, Pages 109-112.
pubmed: 0022-202X
T-Cadherin Is an Auxiliary Negative Regulator of EGFR Pathway Activity in Cutaneous Squamous Cell Carcinoma: Impact on Cell Motility.
Kyriakakis E, Maslova K, Philippova M, Pfaff D, Joshi MB, Buechner SA, Erne P, Resink TJ T-Cadherin Is an Auxiliary Negative Regulator of EGFR Pathway Activity in Cutaneous Squamous Cell Carcinoma: Impact on Cell Motility. J Invest Dermatol. 2012 May 17; Authors: Kyriakakis E, Maslova K, Philippova M, Pfaff D, Joshi MB, Buechner SA, Erne P, Resink TJ Abstract Genetic and epigenetic studies in different cancers, including cutaneous carcinomas, have implicated T-cadherin (T-cad) as a tumor suppressor. Immunohistochemical and in vitro studies have suggested that T-cad loss promotes incipient invasiveness in cutaneous squamous cell carcinoma (SCC). Molecular mechanisms are unknown. This study found that the main consequence of T-cad silencing in SCC is facilitation of ligand-dependent EGFR activation, whereas T-cad overexpression impedes EGFR activation. Gain- and loss-of-function studies in A431 SCC cells demonstrate T-cad-controlled responsiveness to EGF with respect to pharmacological inhibition of EGFR and to diverse signaling and functional events of the EGFR activation cascade (EGFR phosphorylation, internalization, nuclear translocation, cell retraction/de-adhesion, motility, invasion, integrin β1, and Rho small GTPases such as RhoA, Rac1, and Cdc42 activation). Further, T-cad modulates the EGFR pathway activity by influencing membrane compartmentalization of EGFR; T-cad upregulation promotes retention of EGFR in lipid rafts, whereas T-cad silencing releases EGFR from this compartment, rendering EGFR more accessible to ligand stimulation. This study reveals a mechanism for fine-tuning of EGFR activity in SCC, whereby T-cad represents an auxiliary "negative" regulator of the EGFR pathway, which impacts invasion-associated behavioral responses of SCC to EGF. This action of T-cad in SCC may serve as a paradigm explaining other malignancies displaying concomitant T-cad loss and enhanced EGFR activity.Journal of Investigative Dermatology advance online publication, 17 May 2012; doi:10.1038/jid.2012.131. PMID: 22592160 [PubMed - as supplied by publisher]
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Granulocyte-colony Stimulating Factor-producing Primary Cutaneous Anaplastic Large Cell Lymphoma with Cerebral Metastasis.
Kasuya A, Hirakawa S, Hashizume H, Tokura Y Granulocyte-colony Stimulating Factor-producing Primary Cutaneous Anaplastic Large Cell Lymphoma with Cerebral Metastasis. Acta Derm Venereol. 2012 May 8; Authors: Kasuya A, Hirakawa S, Hashizume H, Tokura Y Abstract Abstract is missing (Letter). PMID: 22565644 [PubMed - as supplied by publisher]
Latest Issue of American Journal of Clinical Dermatology
Topical Antimicrobial Treatment of Acne Vulgaris: An Evidence-Based Review
Gamble, RyanDunn, JeffDawson, AnnelisePetersen, BrianMcLaughlin, LaurenSmall, AlisonKindle, ScottDellavalle, Robert P.
Archives of Dermatological Research (Browse Results)
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case–control study
Fri, 11 May 2012 05:53:45 -0000
Abstract Melanoma is one of the most aggressive human cancers. The vitamin D system contributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect to melanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case–control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmental markers used in the clinic today. A panel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00403-012-1243-3Authors Annika Schäfer, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanySteffen Emmert, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyJochen Kruppa, Institute of Medical Biometry and Statistics, University Lübeck, University Hospital Schleswig–Holstein, Campus Lübeck, Maria-Goeppert-Straße 1, 23562 Lübeck, GermanySteffen Schubert, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyMladen Tzvetkov, Department of Clinical Pharmacology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyRotraut Mössner, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyKristian Reich, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyCarola Berking, Department of Dermatology, Ludwig-Maximilians-University of Munich, Frauenlobstrasse 9-11, 80337 Munich, GermanyMatthias Volkenandt, Dermatologikum Hamburg, Stephansplatz 5, 20354 Hamburg, GermanyClaudia Pföhler, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, GermanyMichael P. Schön, Department of Dermatology, Venereology, and Allergology, Georg August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, GermanyThomas Vogt, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, GermanyInke R. König, Institute of Medical Biometry and Statistics, University Lübeck, University Hospital Schleswig–Holstein, Campus Lübeck, Maria-Goeppert-Straße 1, 23562 Lübeck, GermanyJörg Reichrath, Department of Dermatology, Venereology, and Allergology, University Clinic Saarland, Building 18, 66041 Homburg, Germany Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest Articles
The hereditary angioedema burden of illness study in Europe (HAE-BOIS- Europe): background and methodology
Anette BygumEmel Aygören-PürsünTeresa CaballeroKathleen BeusterienShadi GholizadehPatience MusingarimiSuzanne WaitHenrik Boysen Thu, 26 Apr 2012 00:00:00 -0000
Background: Hereditary angioedema (HAE) is a rare but serious disease marked by swelling attacks in the extremities, face, trunk, airway, or abdominal areas that can be spontaneous or the result of trauma and other triggers. It can be life-threatening due to the risk of asphyxiation. While there have been major advancements in our understanding of the immunogenetics of HAE, there are significant gaps in the literature regarding understanding of the humanistic and economic impact of the disease, particularly in Europe. The purpose of the HAE Burden of Illness Study-Europe (HAE-BOIS-Europe), the development and methodology of which is described here, is to better understand the management and impact of HAE from the patient perspective in Europe. Methods: This is a cross-sectional study being conducted in Denmark, Germany and Spain. The study is open to patients ages 12 and older with a diagnosis of HAE-I or HAE-II. Data collection includes: (i) a survey on individuals' health care resource use, direct and indirect medical costs, impact on work and school, treatment satisfaction, and emotional functioning (via the Hospital Anxiety and Depression Scale); and (ii) one-on-one interviews to collect detailed descriptive data and patient testimonials on the impact of HAE on patients' health-related quality of life. Conclusion: The present manuscript describes the development and plans for implementing a multi-country European study with the aim of characterizing the humanistic and economic burden of HAE from the patient perspective. This study will help raise awareness of HAE as a rare but debilitating condition with wide-ranging impacts.
Dermatology : Last 20 articles
Weight Loss and Its Relation to Fat Aspiration Yields in Liposuction: A Survey in 48 Patients
Dermatology (DOI:10.1159/000338894)
pubmed: 1167-1122
(Carpe)DIEM - dermatological indications for electron microscopy: Ehlers Danlos syndrome.
Guenova E, Schaller M (Carpe)DIEM - dermatological indications for electron microscopy: Ehlers Danlos syndrome. Eur J Dermatol. 2012 Jan-Feb;22(1):161 Authors: Guenova E, Schaller M PMID: 22370172 [PubMed - indexed for MEDLINE]
Exogenous Dermatology : Last 20 articles
Author Index Vol. 3, No. 4, 2004
Tue, 31 Jan 2006 00:00:00 +0100
Exog Dermatol 2004;3:201-202 (DOI:10.1159/000091311)
Expert Reviews: Expert Review of Dermatology: Table of Contents
Why are there so few effective treatments for pigmentary disorders of the skin?
info@expert-reviews.com (Rebat M Halder et al) Tue, 27 Mar 2012 18:02:35 -0000
Expert Review of Dermatology , April 2012, Vol. 7, No. 2, Pages 109-112.
pubmed: 0022-202X
T-Cadherin Is an Auxiliary Negative Regulator of EGFR Pathway Activity in Cutaneous Squamous Cell Carcinoma: Impact on Cell Motility.
Kyriakakis E, Maslova K, Philippova M, Pfaff D, Joshi MB, Buechner SA, Erne P, Resink TJ T-Cadherin Is an Auxiliary Negative Regulator of EGFR Pathway Activity in Cutaneous Squamous Cell Carcinoma: Impact on Cell Motility. J Invest Dermatol. 2012 May 17; Authors: Kyriakakis E, Maslova K, Philippova M, Pfaff D, Joshi MB, Buechner SA, Erne P, Resink TJ Abstract Genetic and epigenetic studies in different cancers, including cutaneous carcinomas, have implicated T-cadherin (T-cad) as a tumor suppressor. Immunohistochemical and in vitro studies have suggested that T-cad loss promotes incipient invasiveness in cutaneous squamous cell carcinoma (SCC). Molecular mechanisms are unknown. This study found that the main consequence of T-cad silencing in SCC is facilitation of ligand-dependent EGFR activation, whereas T-cad overexpression impedes EGFR activation. Gain- and loss-of-function studies in A431 SCC cells demonstrate T-cad-controlled responsiveness to EGF with respect to pharmacological inhibition of EGFR and to diverse signaling and functional events of the EGFR activation cascade (EGFR phosphorylation, internalization, nuclear translocation, cell retraction/de-adhesion, motility, invasion, integrin β1, and Rho small GTPases such as RhoA, Rac1, and Cdc42 activation). Further, T-cad modulates the EGFR pathway activity by influencing membrane compartmentalization of EGFR; T-cad upregulation promotes retention of EGFR in lipid rafts, whereas T-cad silencing releases EGFR from this compartment, rendering EGFR more accessible to ligand stimulation. This study reveals a mechanism for fine-tuning of EGFR activity in SCC, whereby T-cad represents an auxiliary "negative" regulator of the EGFR pathway, which impacts invasion-associated behavioral responses of SCC to EGF. This action of T-cad in SCC may serve as a paradigm explaining other malignancies displaying concomitant T-cad loss and enhanced EGFR activity.Journal of Investigative Dermatology advance online publication, 17 May 2012; doi:10.1038/jid.2012.131. PMID: 22592160 [PubMed - as supplied by publisher]
Sites:
Acta Dermato-Venereologica: A journal of clinical and experimental research in the field of dermatology and venereology.American Journal of Dermatopathology: A journal with an emphasis on the pathology of difficult to diagnose skin conditions.
Archives of Dermatological Research: Archives of Dermatological Research - Dermatology. "Archives of Dermatological Research" publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunolog...
Archives of Dermatology: Archives of Dermatology is a monthly professional medical journal published by the American Medical Association. Archives of Dermatology publishes original, peer-reviewed reports and discussions that address the effectiveness of diagnosis and treatment in medical and surgical dermatology, pediat...
Australasian Journal of Dermatology: A journal covering all aspects of dermatology.
British Journal of Dermatology: The Journal of the British Association of Dermatologists. A publication with papers on all aspects of the skin. Interesting for both researchers and clinicians.
Cosmetic Dermatology: dermatology, dermatologist, medical publication, laser, cosmetic, appearance, health, medicine
Cutis: Clinical articles for the Dermatologist, General Practitioner, and Allergist. Focus is on the practical side of dermatology.
Derm101.com: The premier dermatology resource for medical professionals.
Dermatologic Clinics: Each issue focuses on a single topic in dermatology and is presented under the direction of an experienced guest editor.
Dermatology: An international journal which surveys clinical and investigative dermatology.
Dermatology Online Journal: Publication designed to meet reference and education needs of the international dermatologic community. Includes past issues.
Indian Journal of Dermatology: Published on behalf of INDIAN ASSOCIATION OF DERMATOLOGISTS, VENEREOLOGISTS AND LEPROLOGISTS, WEST BENGAL STATE BRANCH.
Indian Journal of Dermatology, Leprology and Venereology: Open Access Publication of IADVL
Journal of Cutaneous Laser Therapy: A journal dealing solely with clinical uses of lasers on the skin.
Journal of Cutaneous Medicine and Surgery: Journal of Cutaneous Medicine and Surgery - Dermatology. Journal of Cutaneous Medicine and Surgery Incorporating Medical & Surgical Dermatology is the Official Journal of the Canadian Dermatology Association/Association cana...
Journal of Investigative Dermatology: The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
Journal of the American Academy of Dermatology: The official monthly publication of the Academy.
Journal Watch Dermatology: Summaries and commentary of dermatology medical journal articles covering topics such as dermatitis, melanoma, and hemangioma.
MedBioWorld: Links to Dentistry & Orthodontics Journals
Pediatric Dermatology: Pediatric Dermatology; journal information, contents lists and abstracts on the Blackwell Publishing webstite.
Postgraduate Dermatology: A publication for dermatology residents and fellows associated with dermatology residency programs.
Skin Therapy Letter: Skin Therapy Letter offers as comprehensive treatment information on various skin conditions including acne, rosacea, psoriasis, psoriatic arthritis, eczema, skin cancer, as well as botox, mild cleansers and lice.
Society for Dermatology and Humanities: Publishes the quarterly Dermanities online journal with a focus on dermatology and the humanities.
The Journal of Dermatological Treatment: This journal deals with all aspects of the treatment of skin disorders.
