submit url • add directory • Nursing jobs ♦ Occupational Nurse jobs
Today's News:
pubmed: 1542-3565
Esophageal Diameter is Decreased in Some Patients with Eosinophilic Esophagitis and Might Increase with Topical Corticosteroid Therapy.
Lee J, Huprich J, Kujath C, Ravi K, Enders F, Smyrk T, Katzka DA, Talley NJ, Alexander JA Esophageal Diameter is Decreased in Some Patients with Eosinophilic Esophagitis and Might Increase with Topical Corticosteroid Therapy. Clin Gastroenterol Hepatol. 2012 Feb 3; Authors: Lee J, Huprich J, Kujath C, Ravi K, Enders F, Smyrk T, Katzka DA, Talley NJ, Alexander JA Abstract BACKGROUND AND AIMS: The rapid response to topical corticosteroids makes it hard to implicate fibrosis as the cause of dysphagia in patients with eosinophilic esophagitis (EoE). We examined surrogates of esophageal expansion using minimal and maximal esophageal diameter (EDmin and EDmax) in barium swallow examinations. METHODS: Eleven patients evaluated at Mayo Clinic Rochester (8 females, median age 40, median diagnosis 36 months, median symptom duration 132 months) underwent barium esophagrams to determine EDmin and EDmax before and after 6 weeks of topical corticosteroid therapy. We assessed parameter reproducibility (in healthy volunteers), baseline EDmin and EDmax, post-corticosteroid changes in EoE patients, and correlation with clinical response. RESULTS: EDmin and EDmax were reproducible, with nonsignificant variance in the 2 esophagrams in controls (P=.44; P=.66, respectively). Baseline EDmax was reduced in EoE at 19 mm (range: 13-26 mm) versus 24 mm (19-29 mm) in controls (P=.004). About 50% of the EoE patients had EDmax and min values within the 10(th) to 90(th) percentile of controls (45% and 55%, respectively). Clinical improvement by Mayo Dsyphagia Questionnaire did not correlate with post-corticosteroid luminal change (p=0.19 for EDmax, p=0.75 for EDmin). Median increases in post-corticosteroid EDmax and EDmin were not statistically significant (P=.15 and .1, respectively). However, they were significant in patients with abnormal baseline EDmax (n=6; 2mm; P=.01) and EDmin (n=5; 3mm; P=.02). CONCLUSIONS: Esophageal diameter is a reproducible parameter that is frequently decreased in EoE, but normal in about 50% of patients. Those with narrowing might respond to steroids, but it is unclear if narrowing causes dysphagia. PMID: 22309879 [PubMed - as supplied by publisher]
Activity-based costing and management in a hospital-based GI unit.
Goldberg MJ, Kosinski L Activity-based costing and management in a hospital-based GI unit. Clin Gastroenterol Hepatol. 2011 Nov;9(11):947-949.e1 Authors: Goldberg MJ, Kosinski L PMID: 22018055 [PubMed - indexed for MEDLINE]
Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome.
Carroccio A, Brusca I, Mansueto P, Soresi M, D'Alcamo A, Ambrosiano G, Pepe I, Iacono G, Lospalluti ML, La Chiusa SM, Di Fede G Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2011 Nov;9(11):965-971.e3 Authors: Carroccio A, Brusca I, Mansueto P, Soresi M, D'Alcamo A, Ambrosiano G, Pepe I, Iacono G, Lospalluti ML, La Chiusa SM, Di Fede G Abstract BACKGROUND & AIMS: Some patients with irritable bowel syndrome (IBS)-like symptoms suffer from food hypersensitivity (FH); their symptoms improve when they are placed on elimination diets. No assays identify patients with FH with satisfactory levels of sensitivity. We determined the frequency of FH among patients with symptoms of IBS and the ability of fecal assays for tryptase, eosinophil cationic protein (ECP), or calprotectin to diagnose FH. METHODS: The study included 160 patients with IBS, 40 patients with other gastrointestinal diseases, and 50 healthy individuals (controls). At the start of the study, patients completed a symptom severity questionnaire, fecal samples were assayed, and levels of specific immunoglobulin E were measured. Patients were observed for 4 weeks, placed on an elimination diet (without cow's milk and derivatives, wheat, egg, tomato, and chocolate) for 4 weeks, and kept a diet diary. Those who reported improvements after the elimination diet period were then diagnosed with FH, based on the results of a double-blind, placebo-controlled, oral food challenge (with cow's milk proteins and then with wheat proteins). RESULTS: Forty of the patients with IBS (25%) were found to have FH. Levels of fecal ECP and tryptase were significantly higher among patients with IBS and FH than those without FH. The ECP assay was the most accurate assay for diagnosis of FH, showing 65% sensitivity and 91% specificity. CONCLUSIONS: Twenty-five percent of patients with IBS have FH. These patients had increased levels of fecal ECP and tryptase, indicating that they might cause inflammation in patients with IBS. Fecal assays for ECP could be used to identify FH in patients with IBS. PMID: 21839707 [PubMed - indexed for MEDLINE]
Nature Reviews Gastroenterology and Hepatology - Issue - nature.com science feeds
Transplantation: Potential of intestinal microbiota profile as a diagnostic biomarker of small bowel transplant rejection
Natalie J. Wood Tue, 17 Jan 2012 00:00:00 -0000
The need to identify a noninvasive marker that is predictive of intestinal allograft rejection may be a step closer to being met, thanks to the finding that small bowel transplant rejection is associated with changes in the intestinal microbiota.“The transplanted gut is a fascinating
Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia
Andy McLarnon Tue, 17 Jan 2012 00:00:00 -0000
Symptoms of functional dyspepsia can be relieved by taking acotiamide, according to researchers from Japan. Patients in a phase III clinical trial had significantly decreased symptom severity compared with controls who took a placebo.“Functional dyspepsia is one of the most common disorders seen in
Transplantation: Expression levels of iron homeostasis genes predict liver graft tolerance
Isobel Franks Tue, 17 Jan 2012 00:00:00 -0000
Most solid organ transplant recipients require life-long administration of immunosuppressants. Occasionally, some recipients develop spontaneous graft tolerance, that is, they are able to maintain stable graft function without receiving immunosuppressive therapy. However, the mechanisms by which this tolerance occurs are not fully understood.Felix Bohne
Subscribe to Gastroenterology RSS feed 
Esophageal Diameter is Decreased in Some Patients with Eosinophilic Esophagitis and Might Increase with Topical Corticosteroid Therapy.
Lee J, Huprich J, Kujath C, Ravi K, Enders F, Smyrk T, Katzka DA, Talley NJ, Alexander JA Esophageal Diameter is Decreased in Some Patients with Eosinophilic Esophagitis and Might Increase with Topical Corticosteroid Therapy. Clin Gastroenterol Hepatol. 2012 Feb 3; Authors: Lee J, Huprich J, Kujath C, Ravi K, Enders F, Smyrk T, Katzka DA, Talley NJ, Alexander JA Abstract BACKGROUND AND AIMS: The rapid response to topical corticosteroids makes it hard to implicate fibrosis as the cause of dysphagia in patients with eosinophilic esophagitis (EoE). We examined surrogates of esophageal expansion using minimal and maximal esophageal diameter (EDmin and EDmax) in barium swallow examinations. METHODS: Eleven patients evaluated at Mayo Clinic Rochester (8 females, median age 40, median diagnosis 36 months, median symptom duration 132 months) underwent barium esophagrams to determine EDmin and EDmax before and after 6 weeks of topical corticosteroid therapy. We assessed parameter reproducibility (in healthy volunteers), baseline EDmin and EDmax, post-corticosteroid changes in EoE patients, and correlation with clinical response. RESULTS: EDmin and EDmax were reproducible, with nonsignificant variance in the 2 esophagrams in controls (P=.44; P=.66, respectively). Baseline EDmax was reduced in EoE at 19 mm (range: 13-26 mm) versus 24 mm (19-29 mm) in controls (P=.004). About 50% of the EoE patients had EDmax and min values within the 10(th) to 90(th) percentile of controls (45% and 55%, respectively). Clinical improvement by Mayo Dsyphagia Questionnaire did not correlate with post-corticosteroid luminal change (p=0.19 for EDmax, p=0.75 for EDmin). Median increases in post-corticosteroid EDmax and EDmin were not statistically significant (P=.15 and .1, respectively). However, they were significant in patients with abnormal baseline EDmax (n=6; 2mm; P=.01) and EDmin (n=5; 3mm; P=.02). CONCLUSIONS: Esophageal diameter is a reproducible parameter that is frequently decreased in EoE, but normal in about 50% of patients. Those with narrowing might respond to steroids, but it is unclear if narrowing causes dysphagia. PMID: 22309879 [PubMed - as supplied by publisher]
Activity-based costing and management in a hospital-based GI unit.
Goldberg MJ, Kosinski L Activity-based costing and management in a hospital-based GI unit. Clin Gastroenterol Hepatol. 2011 Nov;9(11):947-949.e1 Authors: Goldberg MJ, Kosinski L PMID: 22018055 [PubMed - indexed for MEDLINE]
Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome.
Carroccio A, Brusca I, Mansueto P, Soresi M, D'Alcamo A, Ambrosiano G, Pepe I, Iacono G, Lospalluti ML, La Chiusa SM, Di Fede G Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2011 Nov;9(11):965-971.e3 Authors: Carroccio A, Brusca I, Mansueto P, Soresi M, D'Alcamo A, Ambrosiano G, Pepe I, Iacono G, Lospalluti ML, La Chiusa SM, Di Fede G Abstract BACKGROUND & AIMS: Some patients with irritable bowel syndrome (IBS)-like symptoms suffer from food hypersensitivity (FH); their symptoms improve when they are placed on elimination diets. No assays identify patients with FH with satisfactory levels of sensitivity. We determined the frequency of FH among patients with symptoms of IBS and the ability of fecal assays for tryptase, eosinophil cationic protein (ECP), or calprotectin to diagnose FH. METHODS: The study included 160 patients with IBS, 40 patients with other gastrointestinal diseases, and 50 healthy individuals (controls). At the start of the study, patients completed a symptom severity questionnaire, fecal samples were assayed, and levels of specific immunoglobulin E were measured. Patients were observed for 4 weeks, placed on an elimination diet (without cow's milk and derivatives, wheat, egg, tomato, and chocolate) for 4 weeks, and kept a diet diary. Those who reported improvements after the elimination diet period were then diagnosed with FH, based on the results of a double-blind, placebo-controlled, oral food challenge (with cow's milk proteins and then with wheat proteins). RESULTS: Forty of the patients with IBS (25%) were found to have FH. Levels of fecal ECP and tryptase were significantly higher among patients with IBS and FH than those without FH. The ECP assay was the most accurate assay for diagnosis of FH, showing 65% sensitivity and 91% specificity. CONCLUSIONS: Twenty-five percent of patients with IBS have FH. These patients had increased levels of fecal ECP and tryptase, indicating that they might cause inflammation in patients with IBS. Fecal assays for ECP could be used to identify FH in patients with IBS. PMID: 21839707 [PubMed - indexed for MEDLINE]
Nature Reviews Gastroenterology and Hepatology - Issue - nature.com science feeds
Transplantation: Potential of intestinal microbiota profile as a diagnostic biomarker of small bowel transplant rejection
Natalie J. Wood Tue, 17 Jan 2012 00:00:00 -0000
The need to identify a noninvasive marker that is predictive of intestinal allograft rejection may be a step closer to being met, thanks to the finding that small bowel transplant rejection is associated with changes in the intestinal microbiota.“The transplanted gut is a fascinating
Dyspepsia: Acotiamide can relieve symptoms of functional dyspepsia
Andy McLarnon Tue, 17 Jan 2012 00:00:00 -0000
Symptoms of functional dyspepsia can be relieved by taking acotiamide, according to researchers from Japan. Patients in a phase III clinical trial had significantly decreased symptom severity compared with controls who took a placebo.“Functional dyspepsia is one of the most common disorders seen in
Transplantation: Expression levels of iron homeostasis genes predict liver graft tolerance
Isobel Franks Tue, 17 Jan 2012 00:00:00 -0000
Most solid organ transplant recipients require life-long administration of immunosuppressants. Occasionally, some recipients develop spontaneous graft tolerance, that is, they are able to maintain stable graft function without receiving immunosuppressive therapy. However, the mechanisms by which this tolerance occurs are not fully understood.Felix Bohne
Sites:
Endoscopy News: Monthly newspaper that provides clinical news reporting from international, national and regional gastroenterology meetings. It also features original articles, educational reviews, CME monographs and a career opportunities section.atGastroenterology: Specialized search engine focusing on gastroenterology topics.
Baylor College of Medicine Gastroenterology Grand Rounds: Fireworks Splice HTML
Diagnosis health - gastroenterology forum: Information regarding digestive health and causes, diagnosis and treatment of related diseases
Digestive System Diseases from Karolinska Institute: List of resources organized by diseases provided for physicians and patients. List is developed by Karolinska Institute Library of Stockholm.
Electrogastrography: Presents a overview of electrogastrography from methodological point of view, explains the quantitative information that can be extracted from EGG, and discusses clinical studies related to gastric electrical activity
Endotalk: ENDOTALK.com provides comprehensive information regarding the specialty of Gastrointestinal Endoscopy.
Family Practice Notebook - Gastroenterology: Find chapters about Bowel, Cirrhosis, Constipation, Diarrhea, Esophagus, Examination, Hepatitis, Inflammatory Bowel Disease, Malabsorption, Pancreas, Procedure, Peptic Ulcer Disease, Rectum, Spleen, Stomach and Symptom Evaluation. Related chapters from other specialties include Cardiovascular, D...
Gastroenterological Diseases: Virtual Hospital was a digital library of health information in pediatrics, paediatrics, and radiology for pediatric education and radiology education
Gastroenterology jobs: Gastroenterology jobs site with automatic email updates and an extensive directory of recruitment firms.
GastroenterologyWeb: GastroenterologyWeb.com is an educational website for practicing gastroenterologists in the U.S. The site includes feature articles on treatment and diagnosis issues, literature reviews, case studies, video of GI procedures, updates from professional annual meetings, virtual journal club and GI ...
Gastrointestinal Disorders: Information about diseases of the gastrointestinal system as categorized by the Merck Manual.
Gastrointestinal system - CHORUS: CHORUS is a hypertext medical reference. More than 1100 documents describe diseases, anatomy, and radiologic findings.
Gastrosource from AstraZeneca: Gastroenterology resource for healthcare professionals with information on gastrointestinal disease (GI disease), digestive disorders, endoscopy, gastroenterology reports and research.
General Practice Notebook - Gastroenterology: Coverage of this medical speciality.
GILinx: Features gastroenterology news, newsletters, peer-reviewed journal articles, CME, conferences, and medical dictionaries. GILinx and MDLinx aggregate for physicians, health care professionals, residents, med students the most current medical news, journals, and research.
Hardin MD: Gastroenterology and Digestive Diseases: From the University of Iowa, the *best* lists of Internet sources in gastroenterology & intestinal diseases.
Medscape Gastroenterology: Medscape Gastroenterology is a free resource for Physicians, featuring Free Gastroenterology CME (Continuing Medical Education), Gastroenterology medical journal articles, MEDLINE, Gastroenterology medical news, major Gastroenterology conference coverage, and comprehensive drug information.
Princeton Gastroenterology, Associates, P.A.: Princeton Gastroenterology Associates, P.A. located in Princeton NJ with a practice limited to Gastroenterology
