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Current Opinion in Obstetrics and Gynecology - Featured Articles - Editor Picks
Embryo assessment strategies and their validation for clinical use: a critical analysis of methodology
Uyar, Asli; Seli, EmrePurpose of review: A multitude of novel embryo assessment strategies using genomics, transcriptomics, proteomics, and metabolomics approaches are being developed in order to improve upon the currently utilized embryo assessment methods based on morphology and cleavage rate. Although these novel technologies promise significant improvements in clinical outcome for women undergoing infertility treatment with in-vitro fertilization, their validation poses significant challenges. In this review, we discuss the appropriate steps to be taken in clinical validation of an embryo assessment test. We then provide a critical analysis of the studies evaluating embryo assessment strategies from a methodological perspective. Recent findings: Validation of a novel embryo assessment test requires the determination of appropriate performance parameters (such as sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve), followed by clinical validation using appropriate study design. Finally, benefit from a test, alone or in combination with currently used methods, needs to be tested using a prospective randomized controlled trial study design. Few studies on existing or novel embryo assessment methods provide these parameters. Summary: Validation of a test is a rigorous process that needs to be handled meticulously, using appropriate performance parameters determined by the inherent characteristics of the test and clinical studies with appropriate design.
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Embryo assessment strategies and their validation for clinical use: a critical analysis of methodology
Uyar, Asli; Seli, EmrePurpose of review: A multitude of novel embryo assessment strategies using genomics, transcriptomics, proteomics, and metabolomics approaches are being developed in order to improve upon the currently utilized embryo assessment methods based on morphology and cleavage rate. Although these novel technologies promise significant improvements in clinical outcome for women undergoing infertility treatment with in-vitro fertilization, their validation poses significant challenges. In this review, we discuss the appropriate steps to be taken in clinical validation of an embryo assessment test. We then provide a critical analysis of the studies evaluating embryo assessment strategies from a methodological perspective. Recent findings: Validation of a novel embryo assessment test requires the determination of appropriate performance parameters (such as sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve), followed by clinical validation using appropriate study design. Finally, benefit from a test, alone or in combination with currently used methods, needs to be tested using a prospective randomized controlled trial study design. Few studies on existing or novel embryo assessment methods provide these parameters. Summary: Validation of a test is a rigorous process that needs to be handled meticulously, using appropriate performance parameters determined by the inherent characteristics of the test and clinical studies with appropriate design.
Sites:
Gynecology and Reproductive Biology: Publishes original research, reviews and case reports in the fields of obstetrics, prenatal diagnosis, general gynecology and reproductive endocrinology.Archives of Gynecology and Obstetrics: Archives of Gynecology and Obstetrics - Gynecology. "The Archives of Gynecology and Obstetrics" was founded in 1870 as "Archiv für Gynaekologie" and has a long and outstanding tradition. Since 1922 the journal ha...
AWHONN Lifelines: AWHONN Lifelines: journal information, contents and abstracts on the Blackwell Publishing website
Clinical Obstetrics and Gynecology: Each issue covers two topics of interest to practicing obstetricians and gynecologists.
Current Opinion in Obstetrics and Gynecology: Six issues per year with literature reviews, views of the leading experts and annotated references.
Fetal and Maternal Medicine Review: Publishes high quality reviews drawn from all relevant disciplines in this rapidly expanding field.
Green Journal - Obstetrics And Gynecology: Web site for Obstetrics & Gynecology.
International Journal of Gynecological Cancer: International Journal of Gynecological Cancer: journal information, contents lists and abstracts on the Blackwell Publishing website.
International Journal of Gynecological Pathology: Official journal of the International Society of Gynecological Pathologists. Table of contents, author guidelines, editorial board and subscription information.
Journal of Obstetric, Gynecologic and Neonatal Nursing: Journal of Obstetric, Gynecologic, & Neonatal Nursing: information, contents and abstracts on the Blackwell Publishing website.
Journal Of Obstetrics And Gynecology: Reviews advances in Obstetrics and Gynecology. Journal of Obstetrics and Gynecology.
Journal of Pelvic Surgery: Latest research, scientific advances, and clinical experience in the area of pelvic surgery.
MedBioWorld: Links to Obstetrics, Gynecology & Pediatric Journals
Menopause: Research, applied basic science, and clinical guidelines on all aspects of menopause.
Obstetrical and Gynecological Survey: Table of contents, author guidelines, editorial board and subscription information.
Reproductive Medicine Review: Publishes up-to-date reviews of reproductive medicine, particularly in relation to scientific discoveries underpinning developments in clinical practice.
